ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly

@article{Tixeira2019ROCK1BN,
  title={ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly},
  author={Rochelle Tixeira and Thanh Kha Phan and Sarah Caruso and Bo Shi and Georgia K. Atkin-Smith and Christina Nedeva and Jenny D. Y. Chow and Hamsa Puthalakath and Mark D Hulett and M. Jerosch Herold and Ivan K H Poon},
  journal={Cell Death & Differentiation},
  year={2019},
  pages={1-15}
}
Many cell types are known to undergo a series of morphological changes during the progression of apoptosis, leading to their disassembly into smaller membrane-bound vesicles known as apoptotic bodies (ApoBDs). In particular, the formation of circular bulges called membrane blebs on the surface of apoptotic cells is a key morphological step required for a number of cell types to generate ApoBDs. Although apoptotic membrane blebbing is thought to be regulated by kinases including ROCK1, PAK2 and… CONTINUE READING
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