ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity

@inproceedings{NewellLitwa2015ROCK1A2,
  title={ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity},
  author={Karen A. Newell-Litwa and Mathilde Badoual and Hannelore Asmussen and Heather Patel and Leanna Whitmore and Alan F. Horwitz},
  booktitle={The Journal of cell biology},
  year={2015}
}
RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase (ROCK), activates myosin II to form actomyosin filament bundles and large adhesions that locally inhibit and thereby polarize Rac1-driven actin polymerization to the protrusions of migratory fibroblasts and the head of dendritic spines. We have found that the two ROCK isoforms… CONTINUE READING
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