ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration.

@article{OrtzLpez2009ROCKregulatedCD,
  title={ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration.},
  author={Leonardo Ort{\'i}z-L{\'o}pez and Sandra Morales-Mulia and Gerardo Ram{\'i}rez-Rodr{\'i}guez and Gloria Ben{\'i}tez-King},
  journal={Journal of pineal research},
  year={2009},
  volume={46 1},
  pages={15-21}
}
Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted by growth factors and hormones. In particular, the serine threonine kinase activated by the small GTPase Rho, the Rho-associated protein kinase (ROCK), participate in both… CONTINUE READING

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