ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.

@article{Zandi2015ROCKisoformspecificPO,
  title={ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.},
  author={Souska Sophie Zandi and Shintaro Nakao and Kwang-Hoon Chun and Paolo Fiorina and Dawei Sun and Ryotaro Arita and Ming Zhao and Enoch Kim and Olivier Schueller and Stewart Campbell and Mahdi Abbas Taher and Mark Ivan Melhorn and Alexander Stephan Schering and Francesca Gatti and Sara Tezza and Fang Xie and Andrea Vergani and Shigeo Yoshida and Keijiro Ishikawa and Muneo Yamaguchi and Fumiyuki Sasaki and Ruth Schmidt-Ullrich and Yasuaki Hata and Hiroshi Enaida and Mitsuko Yuzawa and Takehiko Yokomizo and Young-Bum Kim and Paul M. Sweetnam and Tatsuro Ishibashi and Ali Hafezi-Moghadam},
  journal={Cell reports},
  year={2015},
  volume={10 7},
  pages={
          1173-86
        }
}
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics in eyes of aged mice, revealing immune changes in aging. ROCK isoforms determine macrophage polarization into M1 and M2 subtypes. M2-like macrophages accumulated in AMD, but not in normal eyes, suggesting that these macrophages may be linked to macular degeneration. M2 macrophages injected into the mouse eye… CONTINUE READING
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