ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.

@article{Wang2009ROCKIR,
  title={ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.},
  author={Yuepeng Wang and Xiaoyu Zheng and Nadeene Riddick and M. Philip Bryden and W. Baur and Xin Zhang and Howard K. Surks},
  journal={Circulation research},
  year={2009},
  volume={104 4},
  pages={531-40}
}
Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in vascular diseases. The RhoA/ROCK signaling pathway is now well recognized to mediate vascular smooth muscle contraction in response to vasoconstrictors by inhibiting myosin phosphatase (MLCP) activity and increasing myosin light chain phosphorylation. Two ROCK isoforms, ROCK1 and ROCK2, are expressed in many tissues, yet the isoform-specific roles of ROCK1 and ROCK2 in vascular smooth muscle and the mechanism of… CONTINUE READING
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References

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Force mapping in epithelial cell migration.

Proceedings of the National Academy of Sciences of the United States of America • 2005

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