ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice
@article{Nakagawa1996ROCKIAR, title={ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice}, author={Osamu Nakagawa and Kazuko Fujisawa and Toshimasa Ishizaki and Yuji Saito and Kazuwa Nakao and Shuh Narumiya}, journal={FEBS Letters}, year={1996}, volume={392} }
723 Citations
Rho-associated coiled-coil containing kinases (ROCK)
- GeologySmall GTPases
- 2014
The structure, regulation, and functions of ROCK are focused on and two mammalian ROCK homologs have been identified, ROCK1 and ROCK2, hereafter collectively referred to as ROCK.
Rational design and improvement of the dimerization‐disrupting peptide selectivity between ROCK‐I and ROCK‐II kinase isoforms in cerebrovascular diseases
- Biology, ChemistryJournal of molecular recognition : JMR
- 2020
Human rho‐associated coiled‐coil forming kinases (ROCKs) ROCK‐I and ROCK‐II have been documented as attractive therapeutic targets for cerebrovascular diseases. Although ROCK‐I and ROCK‐II share a…
Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK‐I and ROCK‐II
- Biology, GeologyGenes to cells : devoted to molecular & cellular mechanisms
- 2011
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
The Rho kinases I and II regulate different aspects of myosin II activity
- BiologyThe Journal of cell biology
- 2005
Analysis of fibroblast adhesion to fibronectin revealed that although ROCK II was more abundant, its activity was always lower than ROCK I, and endogenous ROCKs are distinctly regulated and in turn are involved with different myosin compartments.
Impaired vascular remodeling in yolk sac of embryos deficient in ROCK-I and ROCK-II Running Title
- Biology, Geology
- 2018
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
The Physiology, Pathology, and Therapeutic Interventions for ROCK Isoforms in Diabetic Kidney Disease
- BiologyFrontiers in Pharmacology
- 2020
A conceptual framework for dissecting the molecular underpinnings of ROCK-driven renal injury is provided, focusing on the differences between ROCK1 and ROCK2.
Title Impaired vascular remodeling in the yolk sac of embryos
- Biology, Geology
- 2019
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.
- BiologyCell structure and function
- 2012
Results indicate that the two isoforms of Rho-kinase distribute differentially to accomplish their specific functions, especially at the adherens junctions at the ultrastructural level.
Rho-Kinase in Development and Heart Failure: Insights From Genetic Models
- BiologyPediatric Cardiology
- 2011
Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms.
Rho kinase in the regulation of cell death and survival
- BiologyArchivum Immunologiae et Therapiae Experimentalis
- 2007
This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling in the regulation of apoptosis and highlights new findings from recently generated ROCK-deficient mice.
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