ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

@article{Nakagawa1996ROCKIAR,
  title={ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice},
  author={Osamu Nakagawa and Kazuko Fujisawa and Toshimasa Ishizaki and Yuji Saito and Kazuwa Nakao and Shuh Narumiya},
  journal={FEBS Letters},
  year={1996},
  volume={392}
}
Rho-associated coiled-coil containing kinases (ROCK)
TLDR
The structure, regulation, and functions of ROCK are focused on and two mammalian ROCK homologs have been identified, ROCK1 and ROCK2, hereafter collectively referred to as ROCK.
Rational design and improvement of the dimerization‐disrupting peptide selectivity between ROCK‐I and ROCK‐II kinase isoforms in cerebrovascular diseases
Human rho‐associated coiled‐coil forming kinases (ROCKs) ROCK‐I and ROCK‐II have been documented as attractive therapeutic targets for cerebrovascular diseases. Although ROCK‐I and ROCK‐II share a
Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK‐I and ROCK‐II
TLDR
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
The Rho kinases I and II regulate different aspects of myosin II activity
TLDR
Analysis of fibroblast adhesion to fibronectin revealed that although ROCK II was more abundant, its activity was always lower than ROCK I, and endogenous ROCKs are distinctly regulated and in turn are involved with different myosin compartments.
Impaired vascular remodeling in yolk sac of embryos deficient in ROCK-I and ROCK-II Running Title
TLDR
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
The Physiology, Pathology, and Therapeutic Interventions for ROCK Isoforms in Diabetic Kidney Disease
TLDR
A conceptual framework for dissecting the molecular underpinnings of ROCK-driven renal injury is provided, focusing on the differences between ROCK1 and ROCK2.
Title Impaired vascular remodeling in the yolk sac of embryos
TLDR
The results suggest that ROCK isoforms function redundantly during embryogenesis and play a critical role in vascular development.
Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.
TLDR
Results indicate that the two isoforms of Rho-kinase distribute differentially to accomplish their specific functions, especially at the adherens junctions at the ultrastructural level.
Rho-Kinase in Development and Heart Failure: Insights From Genetic Models
TLDR
Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiologic, and pathophysiologic functions of the two ROCK isoforms.
Rho kinase in the regulation of cell death and survival
TLDR
This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling in the regulation of apoptosis and highlights new findings from recently generated ROCK-deficient mice.
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TLDR
P purified a Rho‐interacting protein with a molecular mass of approximately 164 kDa (p164) from bovine brain that bound to GTPgammaS (a non‐hydrolyzable GTP analog) and is likely to be a putative target serine/threonine kinase for Rho and serves as a mediator of the RHo‐dependent signaling pathway.
The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
TLDR
It is shown that p160 can associate physically and functionally with Rho both in vitro and in vivo, indicating that the small GTP‐binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation.
A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes (*)
TLDR
The isolation of a rat cDNA encoding a 150-kDa protein, which specifically binds RhoA in its GTP form and contains an N-terminal serine/threonine kinase domain highly related to the human myotonic dystrophy kinase and a cysteine-rich domain toward the C terminus is reported.
Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho
TLDR
This study indicates that a serine-threonine protein kinase is a Rho effector and presents an amino acid sequence motif for binding to GTP-Rho that may be shared by a family of Rho target proteins.
Signal transduction pathways regulating Rho‐mediated stress fibre formation: requirement for a tyrosine kinase.
TLDR
Genistein inhibited the Rho‐dependent clustering of phosphotyrosine‐containing proteins at focal adhesions, and the increased tyrosine phosphorylation of several proteins including pp125FAK, induced by LPA and bombesin, suggesting a model where RHo‐induced activation of a tyrosinesine kinase is required for the formation of stress fibres.
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