RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

@article{Malathi2010RNaseLR,
  title={RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.},
  author={K. Malathi and T. Saito and Nannette Crochet and D. Barton and M. Gale and R. Silverman},
  journal={RNA},
  year={2010},
  volume={16 11},
  pages={
          2108-19
        }
}
Triggering and propagating an intracellular innate immune response is essential for control of viral infections. RNase L is a host endoribonuclease and a pivotal component of innate immunity that cleaves viral and cellular RNA within single-stranded loops releasing small structured RNAs with 5'-hydroxyl (5'-OH) and 3'-monophosphoryl (3'-p) groups. In 2007, we reported that RNase L cleaves self RNA to produce small RNAs that function as pathogen-associated molecular patterns (PAMPs). However… Expand
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