RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.

@article{Khabar2003RNaseLM,
  title={RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.},
  author={Khalid S. A. Khabar and Yunus M. Siddiqui and Fahad al-Zoghaibi and Latifa Al-Haj and Mohammed Dhalla and Aimin Zhou and Beihua Dong and Mark Whitmore and Jayashree M. Paranjape and Mohammed N. Al-Ahdal and Futwan A. Al-Mohanna and Bryan R. G. Williams and Robert H. Silverman},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 22},
  pages={20124-32}
}
The transient control of diverse biological responses that occurs in response to varied forms of stress is often a highly regulated process. During the interferon (IFN) response, translational repression due to phosphorylation of eukaryotic initiation factor 2alpha, eIF2alpha, by the double-stranded RNA-dependent protein kinase, PKR, constitutes a means of inhibiting viral replication. Here we show that the transient nature of the IFN response against acute viral infections is regulated, at… CONTINUE READING