RNase III autoregulation: structure and function of rncO, the posttranscriptional "operator".

@article{Matsunaga1996RNaseIA,
  title={RNase III autoregulation: structure and function of rncO, the posttranscriptional "operator".},
  author={James Matsunaga and Elwyn L. Simons and Robert W. Simons},
  journal={RNA},
  year={1996},
  volume={2 12},
  pages={1228-40}
}
Expression of the Escherichia coli rnc-era-recO operon is regulated posttranscriptionally by ribonuclease III (RNase III), encoded in the rnc gene. RNase III initiates rapid decay of the rnc operon mRNA by cleaving a double-stranded region of the rnc leader. This region, termed rncO, is portable, conferring stability and RNase III regulation to heterologous RNAs. Here, we report the detailed analysis of rncO structure and function. The first 215 nt of the rnc leader are sufficient for its… CONTINUE READING
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