RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability.

@article{Wahba2011RNaseHA,
  title={RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability.},
  author={Lamia Wahba and Jeremy D Amon and Douglas Koshland and Milena Vuica-Ross},
  journal={Molecular cell},
  year={2011},
  volume={44 6},
  pages={
          978-88
        }
}
Genome instability, a hallmark of cancer progression, is thought to arise through DNA double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs and instability can occur through RNA:DNA hybrids generated by defects in RNA elongation and splicing. We report that in yeast hybrids naturally form at many loci in wild-type cells, likely due to transcriptional errors, but are removed by two evolutionarily conserved RNase H enzymes. Mutants defective in transcriptional… CONTINUE READING
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