RNase H activity: structure, specificity, and function in reverse transcription.

@article{Schultz2008RNaseHA,
  title={RNase H activity: structure, specificity, and function in reverse transcription.},
  author={Sharon J Schultz and James J. Champoux},
  journal={Virus research},
  year={2008},
  volume={134 1-2},
  pages={
          86-103
        }
}
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This review compares the well-studied RNase H activities of human immunodeficiency virus, type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. [...] Key Result The RNase H domains of HIV-1 and MoMLV are structurally very similar, with functions assigned to conserved subregions like the RNase H primer grip and the connection subdomain, as well as to distinct features like the C-helix and loop in MoMLV RNase H. Like cellular RNases H, catalysis by the retroviral enzymes appears to…Expand Abstract

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