RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

@article{Mailand2007RNF8UH,
  title={RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins},
  author={N. Mailand and S. Bekker-Jensen and Helene Faustrup and Fredrik Melander and J. Bartek and C. Lukas and J. Lukas},
  journal={Cell},
  year={2007},
  volume={131},
  pages={887-900}
}
  • N. Mailand, S. Bekker-Jensen, +4 authors J. Lukas
  • Published 2007
  • Medicine, Biology
  • Cell
  • Accumulation of repair proteins on damaged chromosomes is required to restore genomic integrity. However, the mechanisms of protein retention at the most destructive chromosomal lesions, the DNA double-strand breaks (DSBs), are poorly understood. We show that RNF8, a RING-finger ubiquitin ligase, rapidly assembles at DSBs via interaction of its FHA domain with the phosphorylated adaptor protein MDC1. This is accompanied by an increase in DSB-associated ubiquitylations and followed by… CONTINUE READING

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