RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

@article{Huen2007RNF8TT,
  title={RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly},
  author={Michael S. Y. Huen and Robert R Grant and Isaac A. Manke and Kay T Minn and Xiaochun Yu and Michael B. Yaffe and Junjie Chen},
  journal={Cell},
  year={2007},
  volume={131},
  pages={901-914}
}
DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellular senescence, and apoptosis. Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA-damage response. We have solved the X-ray crystal structure of the FHA domain structure at 1.35 A. We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged… CONTINUE READING
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