RNF43 interacts with NEDL1 and regulates p53-mediated transcription.

Abstract

The ubiquitin-proteasomal system plays a crucial role in oncogenesis in colorectal tissues. Recent studies have shown that stability of β-catenin, which functions as an oncogene for colorectal cancer, is regulated by ubiquitin-mediated degradation. It has been reported that a putative E3 ubiquitin ligase, RNF43, is highly expressed in human colorectal… (More)
DOI: 10.1016/j.bbrc.2010.11.082

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