RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

@article{Guzzo2012RNF4dependentHS,
  title={RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.},
  author={Catherine M. Guzzo and Christopher E Berndsen and Jianmei Zhu and Vibhor Gupta and Ajit Bikram Datta and Roger A. Greenberg and Cynthia Wolberger and Michael J Matunis},
  journal={Science signaling},
  year={2012},
  volume={5 253},
  pages={ra88}
}
The DNA repair function of the breast cancer susceptibility protein BRCA1 depends in part on its interaction with RAP80, which targets BRCA1 to DNA double-strand breaks (DSBs) through recognition of K63-linked polyubiquitin chains. The localization of BRCA1 to DSBs also requires sumoylation. We demonstrated that, in addition to having ubiquitin-interacting motifs, RAP80 also contains a SUMO-interacting motif (SIM) that is critical for recruitment to DSBs. In combination with the ubiquitin… CONTINUE READING
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