RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α

@inproceedings{Hagen2010RNF4AV,
  title={RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α},
  author={Martijn van Hagen and Ren{\'e} M. Overmeer and Sharareh S. Abolvardi and Alfred Cornelis Otto Vertegaal},
  booktitle={Nucleic acids research},
  year={2010}
}
Hypoxia-inducible factors (HIFs) are critical transcription factors that mediate cell survival during reduced oxygen conditions (hypoxia). At regular oxygen conditions (normoxia), HIF-1alpha and HIF-2alpha are continuously synthesized in cells and degraded via the ubiquitin-proteasome pathway. During hypoxia, these proteins are stabilized and translocate to the nucleus to activate transcription of target genes that enable cell survival at reduced oxygen levels. HIF proteins are tightly… CONTINUE READING
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