RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

  title={RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis},
  author={April G Reynolds and Huanyu Qiao and Ye Yang and Jefferson K. Chen and Neil Jackson and Kajal Biswas and J. Kim Holloway and Fr{\'e}d{\'e}ric Baudat and Bernard de Massy and Jeremy Wang and Christer H{\"o}{\"o}g and Paula E. Cohen and Neil Hunter},
  journal={Nature Genetics},
Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of chromosomes obtains at least one crossover, even though the majority of recombination sites yield non-crossovers. A putative regulator of crossing-over is RNF212, which is associated with variation in crossover rates in humans. We show that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Selective… CONTINUE READING
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