RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

@article{Mattiroli2012RNF168UK,
  title={RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling},
  author={Francesca Mattiroli and Joseph H. A. Vissers and Willem J. van Dijk and Pauline T. Ikpa and Elisabetta Citterio and Wim Vermeulen and Jurgen A Marteijn and Titia Sixma},
  journal={Cell},
  year={2012},
  volume={150},
  pages={1182-1195}
}
Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. Here, we show that RNF8 is inactive toward nucleosomal H2A, whereas RNF168 catalyzes the… CONTINUE READING
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