RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

@inproceedings{Poulsen2013RNF111ArkadiaIA,
  title={RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response},
  author={Sara Lund Poulsen and Rebecca Kring Hansen and Sebastian Wagner and Loes van Cuijk and Gijsbert J. van Belle and Werner W. Streicher and Mats Wikstr{\"o}m and Chunaram Choudhary and Adriaan B. Houtsmuller and Jurgen A Marteijn and Simon Bekker-Jensen and Niels Mailand},
  booktitle={The Journal of cell biology},
  year={2013}
}
Protein modifications by ubiquitin and small ubiquitin-like modifier (SUMO) play key roles in cellular signaling pathways. SUMO-targeted ubiquitin ligases (STUbLs) directly couple these modifications by selectively recognizing SUMOylated target proteins through SUMO-interacting motifs (SIMs), promoting their K48-linked ubiquitylation and degradation. Only a single mammalian STUbL, RNF4, has been identified. We show that human RNF111/Arkadia is a new STUbL, which used three adjacent SIMs for… CONTINUE READING