RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

@inproceedings{Venter2015RNDtypeDE,
  title={RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition},
  author={Henrietta Venter and Rumana Mowla and Thelma Ohene-Agyei and Shutao Ma},
  booktitle={Front. Microbiol.},
  year={2015}
}
Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance in the presence of an active efflux pump. The substrate range of drug efflux pumps is not limited to antibiotics, but it also includes toxins, dyes, detergents, lipids, and molecules involved in quorum sensing; hence efflux pumps are also associated with virulence and biofilm formation. Inhibitors of efflux pumps are… CONTINUE READING
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