RNAs that interact with the fragile X syndrome RNA binding protein FMRP.

@article{Sung2000RNAsTI,
  title={RNAs that interact with the fragile X syndrome RNA binding protein FMRP.},
  author={Ying Ju Sung and James Conti and Julia R. Currie and William Ted Brown and Robert B. Denman},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={275 3},
  pages={973-80}
}
The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential display (DDRT-PCR) and cloned and their identities determined. Nine candidate RNAs were isolated; five RNAs, including FMR1 mRNA, encoded known proteins. Four others were novel. The… CONTINUE READING
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