RNAi therapeutics: a potential new class of pharmaceutical drugs

@article{Bumcrot2006RNAiTA,
  title={RNAi therapeutics: a potential new class of pharmaceutical drugs},
  author={David A. Bumcrot and Muthiah Manoharan and Victor Koteliansky and Dinah W. Y. Sah},
  journal={Nature Chemical Biology},
  year={2006},
  volume={2},
  pages={711-719}
}
The rapid identification of highly specific and potent drug candidates continues to be a substantial challenge with traditional pharmaceutical approaches. Moreover, many targets have proven to be intractable to traditional small-molecule and protein approaches. Therapeutics based on RNA interference (RNAi) offer a powerful method for rapidly identifying specific and potent inhibitors of disease targets from all molecular classes. Numerous proof-of-concept studies in animal models of human… CONTINUE READING

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