RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo.

@article{Zhou2009RNAiTU,
  title={RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo.},
  author={Hao Zhou and Yaling Tang and Xinhua Liang and Xiaoqin Yang and Jing Yang and Guiquan Zhu and Min Zheng and Chunxu Zhang},
  journal={International journal of cancer},
  year={2009},
  volume={125 2},
  pages={
          453-62
        }
}
It has been admitted that urokinase-type plasminogen activator receptor (u-PAR) is overexpressed in many human malignant tumors including oral squamous cell carcinoma (OSCC) and plays an important role in a variety of cancer key cellular events as a versatile signaling orchestrator. In our study, a retroviral vector expressing u-PAR-specific siRNA was injected into OSCC xenografts of nude mice to observe its inhibitory effects on OSCC. Our data demonstrate that siRNA targeting u-PAR markedly… CONTINUE READING
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uPAR: a versatile signalling orchestrator

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