RNAi targeting urokinase‐type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo

@article{Zhou2009RNAiTU,
  title={RNAi targeting urokinase‐type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo},
  author={H. Zhou and Y. Tang and Xinhua Liang and X. Yang and J. Yang and G. Zhu and Min Zheng and Chunxu Zhang},
  journal={International Journal of Cancer},
  year={2009},
  volume={125}
}
  • H. Zhou, Y. Tang, +5 authors Chunxu Zhang
  • Published 2009
  • Biology, Medicine
  • International Journal of Cancer
  • It has been admitted that urokinase‐type plasminogen activator receptor (u‐PAR) is overexpressed in many human malignant tumors including oral squamous cell carcinoma (OSCC) and plays an important role in a variety of cancer key cellular events as a versatile signaling orchestrator. In our study, a retroviral vector expressing u‐PAR‐specific siRNA was injected into OSCC xenografts of nude mice to observe its inhibitory effects on OSCC. Our data demonstrate that siRNA targeting u‐PAR markedly… CONTINUE READING
    36 Citations
    WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C
    • 17
    • PDF
    Glycogen synthase kinase 3 beta: can it be a target for oral cancer
    • R. Mishra
    • Biology, Medicine
    • Molecular Cancer
    • 2009
    • 163
    Ani-survivin DNAzymes inhibit cell proliferation and migration in breast cancer cell line MCF-7.
    • 8
    • Highly Influenced
    • PDF
    Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase
    • 19
    • Highly Influenced

    References

    SHOWING 1-10 OF 68 REFERENCES
    RNAi-mediated downregulation of urokinase plasminogen activator receptor inhibits proliferation, adhesion, migration and invasion in oral cancer cells.
    • 31
    The urokinase‐type plasminogen activator system in cancer metastasis: A review
    • 1,510
    Stable transfection of urokinase-type plasminogen activator antisense construct modulates invasion of human glioblastoma cells.
    • S. Mohanam, S. Jasti, +10 authors J. S. Rao
    • Biology, Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 2001
    • 34
    • PDF
    Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells
    • 99
    • PDF
    Downregulation of urokinase-type plasminogen activator receptor (uPAR) induces caspase-mediated cell death in human glioblastoma cells
    • 26