RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway.

Abstract

Klotho is a recently identified antiaging gene. Brain endothelin-1 (ET1) is important in the regulation of blood pressure (BP). We hypothesized that silence of brain klotho potentiates cold-induced elevation of BP via the endothelin pathway. To silence brain klotho, we constructed adeno-associated virus (AAV) carrying rat klotho small interference hairpin… (More)
DOI: 10.1152/physiolgenomics.00192.2009

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@article{Wang2010RNAiSO, title={RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway.}, author={Xiuqing Wang and Zhongjie Sun}, journal={Physiological genomics}, year={2010}, volume={41 2}, pages={120-6} }