RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.

@article{Tyner2008RNAiSO,
  title={RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.},
  author={Jeffrey W. Tyner and Denise Katherine Walters and Stephanie G. Willis and Mary Luttropp and Jason J Oost and Marc M. Loriaux and Heidi Erickson and Amie S. Corbin and Thomas O'Hare and Michael C Heinrich and Michael Werner Nikolaus Deininger and Brian J. Druker},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={2238-45}
}
Despite vast improvements in our understanding of cancer genetics, a large percentage of cancer cases present without knowledge of the causative genetic events. Tyrosine kinases are frequently implicated in the pathogenesis of numerous types of cancer, but identification and validation of tyrosine kinase targets in cancer can be a time-consuming process. We report the establishment of an efficient, functional screening assay using RNAi technology to directly assess and compare the effect of… CONTINUE READING

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