RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.

@article{Cellot2013RNAiSI,
  title={RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.},
  author={Sonia Cellot and Kristin J. Hope and Jalila Chagraoui and Martin Sauvageau and {\'E}ric Deneault and Tara Macrae and Nadine Mayotte and Brian T. Wilhelm and Josette Ren{\'e}e Landry and S. B. Ting and Jana Krosl and Keith Humphries and Alexander Thompson and Guy Sauvageau},
  journal={Blood},
  year={2013},
  volume={122 9},
  pages={1545-55}
}
Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain-containing family of demethylases comprises 27 members that target mono-, di-, and trimethylated lysine residues of histone (or nonhistone) proteins. To evaluate their role in regulation of hematopoietic stem cell (HSC) behavior, we performed an in vivo RNAi-based functional screen and demonstrated that Jarid1b and Jhdm1f play opposing roles in regulation of HSC… CONTINUE READING

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RNAi screen identifies Jarid 1 b as a major regulator of mouse HSC activity

  • J. Chagraoui, M. Sauvageau, É. Deneault
  • Blood
  • 2013

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