RNAi methods and screening: RNAi based high-throughput genetic interaction screening.

@article{Cipriani2011RNAiMA,
  title={RNAi methods and screening: RNAi based high-throughput genetic interaction screening.},
  author={Patricia G. Cipriani and Fabio Piano},
  journal={Methods in cell biology},
  year={2011},
  volume={106},
  pages={89-111}
}
Expanding on decades of mutational analyses, numerous genome-scale RNAi screens have now been performed in C. elegans, leading to estimates that the majority of genes with essential functions that can be revealed by single-gene perturbations have already been identified in this organism. To build on this basic foundation and uncover condition-dependent or… CONTINUE READING