RNAi-mediated silencing of AQP1 expression inhibited the proliferation, invasion and tumorigenesis of osteosarcoma cells.

@article{Wu2015RNAimediatedSO,
  title={RNAi-mediated silencing of AQP1 expression inhibited the proliferation, invasion and tumorigenesis of osteosarcoma cells.},
  author={Zhong Xing Wu and Shaohua Li and Jie Liu and Yongzhen Shi and Jianguang Wang and Dong Chen and Linjie Luo and Yongqiang Qian and Xiang Huang and Hua Wang},
  journal={Cancer biology & therapy},
  year={2015},
  volume={16 9},
  pages={1332-40}
}
Aquaporin 1 (AQP1), a member of water channel proteins, functions as a water-selective transporting protein in cell membranes. In recent years, AQP1 has been found to be overexpressed in various tumors. However, the molecular mechanism underlying the biological function of AQP1 in osteosarcoma is still unclear. This study was aimed at elucidating the roles of AQP1 in regulating the biological behavior of osteosarcoma cells. In this study, we found that AQP1 mRNA was elevated in osteosarcoma… CONTINUE READING
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