RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors

@article{Schaser2011RNAimediatedGS,
  title={RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors},
  author={Thomas Schaser and Christian Wrede and Lydia J Duerner and Katja Sliva and Klaus Cichutek and Barbara S. Schnierle and C J Buchholz},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={953-960}
}
RNAi represents a powerful technology to specifically downregulate the expression of target genes. For cancer research and therapy, an efficient in vivo delivery system is supposed to distribute RNAi to all tumour cells upon systemic administration. We present replication-competent murine leukaemia virus (MLV) vectors, which deliver RNAi to tumour tissue upon tail vein injection. In HT1080 cells stably expressing GFP or luciferase, GFP expression was suppressed by more than 80% and luciferase… CONTINUE READING
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