RNAi-mediated downregulation of oral cancer overexpressed 1 (ORAOV1) inhibits vascular endothelial cell proliferation, migration, invasion, and tube formation.

@article{Zhao2016RNAimediatedDO,
  title={RNAi-mediated downregulation of oral cancer overexpressed 1 (ORAOV1) inhibits vascular endothelial cell proliferation, migration, invasion, and tube formation.},
  author={Xin Zhao and Dongjuan Liu and Li-li Wang and Ruiqing Wu and Xin Zeng and Hongxia Dan and Ning Ji and Lu Jiang and Yu Zhou and Qianming Chen},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  year={2016},
  volume={45 4},
  pages={256-61}
}
BACKGROUND Oral squamous cell carcinoma (OSCC) is one of the top ten tumors threatening human health. Oral cancer overexpressed 1 (ORAOV1) identified within chromosomal region 11q13, one of the most frequently amplified regions in OSCC, has been suggested as a novel candidate oncogene in OSCC, regulating cell cycle, apoptosis, and angiogenesis. In this study, we investigated the role of ORAOV1 in OSCC-induced angiogenesis in vitro. METHODS EA.hy926 human endothelial cells were co-cultured… CONTINUE READING