RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.

@article{Walsh2011RNAiKO,
  title={RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.},
  author={Naomi Walsh and Annemarie Larkin and Niall Swan and Kevin Conlon and Paul Dowling and Ray McDermott and Martin M. Clynes},
  journal={Cancer letters},
  year={2011},
  volume={306 2},
  pages={180-9}
}
We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting Hop, signalling pathways modulating invasion and client protein stabilisation involving Hsp90-dependent complexes may be altered. In this study, we show that Hop knockdown by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

E

  • H. Kubota, S. Yamamoto
  • Itoh, et al., Increased expression of cochaperone…
  • 2010
1 Excerpt

N

  • N. Walsh
  • O’Donovan, S. Kennedy, M. Henry, P. Meleady, M…
  • 2009

Similar Papers

Loading similar papers…