RNAi-induced down-regulation of Mecp2 expression in the rat brain.


The MECP2 (methyl-CpG-binding protein 2) gene has been implicated in the pathogenesis of Rett Syndrome. A rat model with a down-regulated Mecp2 was established using a recombinant lentiviral vector expressing small hairpin RNA of the rat Mecp2 gene. Four recombinant vectors were constructed by inserting sequences of small hairpin RNA targeting the rat Mecp2… (More)
DOI: 10.1016/j.ijdevneu.2008.02.009


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@article{Jin2008RNAiinducedDO, title={RNAi-induced down-regulation of Mecp2 expression in the rat brain.}, author={Jing Jin and Xinhua Bao and Hansen Wang and Hong Pan and Yuzhi Zhang and Xiru Wu}, journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience}, year={2008}, volume={26 5}, pages={457-65} }