RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa.

@article{Chicas2004RNAidependentAR,
  title={RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa.},
  author={Agustin Chicas and Carlo Cogoni and Giuseppe Macino},
  journal={Nucleic acids research},
  year={2004},
  volume={32 14},
  pages={
          4237-43
        }
}
RNA interference (RNAi) can silence genes at the transcriptional level by targeting locus-specific Lys9H3 methylation or at the post-transcriptional level by targeting mRNA degradation. Here we have cloned and sequenced genomic regions methylated in Lys9H3 in Neurospora crassa to test the requirements for components of the RNAi pathway in this modification. We find that 90% of clones map to repeated sequences and relics of transposons that have undergone repeat-induced point mutations (RIP). We… CONTINUE READING

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