RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer.

@article{Lunavat2016RNAiDB,
  title={RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer.},
  author={Taral R Lunavat and Su Chul Jang and Lisa M. Nilsson and Hyun Taek Park and Gabriela Repiska and Cecilia L{\"a}sser and Jonas Nilsson and Yong Song Gho and Jan L{\"o}tvall},
  journal={Biomaterials},
  year={2016},
  volume={102},
  pages={231-8}
}
To develop RNA-based therapeutics, it is crucial to create delivery vectors that transport the RNA molecule into the cell cytoplasm. Naturally released exosomes vesicles (also called "Extracellular Vesicles") have been proposed as possible RNAi carriers, but their yield is relatively small in any cell culture system. We have previously generated exosome-mimetic nanovesicles (NV) by serial extrusions of cells through nano-sized filters, which results in 100-times higher yield of extracellular… CONTINUE READING
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