RNAi-based therapeutics–current status, challenges and prospects

  title={RNAi-based therapeutics–current status, challenges and prospects},
  author={Katrin Tiemann and John J. Rossi},
  booktitle={EMBO molecular medicine},
RNA interference (RNAi) is a collection of small RNA directed mechanisms that result in sequence specific inhibition of gene expression. The notion that RNAi could lead to a new class of therapeutics caught the attention of many investigators soon after its discovery. The field of applied RNAi therapeutics has moved very quickly from lab to bedside. The RNAi approach has been widely used for drug development and several phase I and II clinical trials are under way. However, there are still some… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 98 extracted citations

Therapeutic potentials of short interfering RNAs

Applied Microbiology and Biotechnology • 2017
View 4 Excerpts
Highly Influenced

siRNA: a new approach to target neuropathic pain.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy • 2012
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 70 references

Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 4 Excerpts
Highly Influenced

Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol.

Molecular therapy : the journal of the American Society of Gene Therapy • 2008
View 1 Excerpt

Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy.

Molecular therapy : the journal of the American Society of Gene Therapy • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…