RNAi-based therapeutics–current status, challenges and prospects

@inproceedings{Tiemann2009RNAibasedTS,
  title={RNAi-based therapeutics–current status, challenges and prospects},
  author={Katrin Tiemann and John J. Rossi},
  booktitle={EMBO molecular medicine},
  year={2009}
}
RNA interference (RNAi) is a collection of small RNA directed mechanisms that result in sequence specific inhibition of gene expression. The notion that RNAi could lead to a new class of therapeutics caught the attention of many investigators soon after its discovery. The field of applied RNAi therapeutics has moved very quickly from lab to bedside. The RNAi approach has been widely used for drug development and several phase I and II clinical trials are under way. However, there are still some… CONTINUE READING
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