RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing.

@article{Conde2015RNAibasedGT,
  title={RNAi-based glyconanoparticles trigger apoptotic pathways for in vitro and in vivo enhanced cancer-cell killing.},
  author={Jo{\~a}o Conde and Furong Tian and Yul{\'a}n Hern{\'a}ndez and Chenchen Bao and Pedro Vieira Baptista and Daxiang Cui and Tobias Stoeger and Jes{\'u}s Mart{\'i}nez de la Fuente},
  journal={Nanoscale},
  year={2015},
  volume={7 19},
  pages={9083-91}
}
Gold glyconanoparticles (GlycoNPs) are full of promise in areas like biomedicine, biotechnology and materials science due to their amazing physical, chemical and biological properties. Here, siRNA GlycoNPs (AuNP@PEG@Glucose@siRNA) in comparison with PEGylated GlycoNPs (AuNP@PEG@Glucose) were applied in vitro to a luciferase-CMT/167 adenocarcinoma cancer cell line and in vivo via intratracheal instillation directly into the lungs of B6 albino mice grafted with luciferase-CMT/167 adenocarcinoma… CONTINUE READING