RNAi Effector Diversity in Nematodes

  title={RNAi Effector Diversity in Nematodes},
  author={Johnathan J Dalzell and Paul McVeigh and Neil D. Warnock and Makedonka Dautova Mitreva and David McK. Bird and Pierre Abad and Colin C. Fleming and Tim Day and Angela Mousley and Nikki J. Marks and Aaron G Maule},
  booktitle={PLoS neglected tropical diseases},
While RNA interference (RNAi) has been deployed to facilitate gene function studies in diverse helminths, parasitic nematodes appear variably susceptible. To test if this is due to inter-species differences in RNAi effector complements, we performed a primary sequence similarity survey for orthologs of 77 Caenorhabditis elegans RNAi pathway proteins in 13 nematode species for which genomic or transcriptomic datasets were available, with all outputs subjected to domain-structure verification… CONTINUE READING


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