RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements

@article{Grimaud2006RNAiCA,
  title={RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements},
  author={Charlotte Grimaud and Fr{\'e}d{\'e}ric Bantignies and Manika Pal-Bhadra and Pallavi Ghana and Utpal Bhadra and Giacomo Cavalli},
  journal={Cell},
  year={2006},
  volume={124},
  pages={957-971}
}
Drosophila Polycomb group (PcG) proteins silence homeotic genes through binding to Polycomb group response elements (PREs). Fab-7 is a PRE-containing regulatory element from the homeotic gene Abdominal-B. When present in multiple copies in the genome, Fab-7 can induce long-distance gene contacts that enhance PcG-dependent silencing. We show here that components of the RNA interference (RNAi) machinery are involved in PcG-mediated silencing at Fab-7 and in the production of small RNAs at… CONTINUE READING
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