RNAi: a novel antisense technology and its therapeutic potential.

  title={RNAi: a novel antisense technology and its therapeutic potential.},
  author={Anne Dallas and Alexander V Vlassov},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  volume={12 4},
Antisense oligonucleotide agents induce the inhibition of target gene expression in a sequence-specific manner by exploiting the ability of oligonucleotides to bind to target RNAs via Watson-Crick hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. This technology may be used for therapeutic purposes, functional genomics, and target validation. There are three major categories of gene-silencing molecules: (1) antisense oligonucleotide… CONTINUE READING
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