RNAi: RISC Gets Loaded

@article{Preall2005RNAiRG,
  title={RNAi: RISC Gets Loaded},
  author={Jonathan B. Preall and Erik J Sontheimer},
  journal={Cell},
  year={2005},
  volume={123},
  pages={543-545}
}
When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two approximately 21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities. 

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

siRNA vs. shRNA: similarities and differences.

Advanced drug delivery reviews • 2009
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-8 of 8 references

Cell

T A Rand, S Peterson, F Du, Wang
Cell • 2005

Genes Dev

C Kanellopoulou, S A Muljo, +5 authors K Rajewsky
Genes Dev • 2005
View 1 Excerpt

Nucleic Acids Res

S D Rose, D H Kim, +5 authors M A Behlke
Nucleic Acids Res • 2005

Proc. Natl. Acad. Sci. USA 102

E P Murchison, J F Partridge, O H Tam, S Cheloufi, G J Hannon
Proc. Natl. Acad. Sci. USA 102 • 2005
View 1 Excerpt

Mol. Cell

G Meister, M Landthaler, +3 authors T Tuschl
Mol. Cell • 2004
View 1 Excerpt

Nat. Struct. Mol. Biol

B Haley, P D Zamore
Nat. Struct. Mol. Biol • 2004

Science

J Liu, M A Carmell, +6 authors G J Hannon
Science • 2004
View 1 Excerpt

J. Biol. Chem

J W Pham, E J Sontheimer
J. Biol. Chem • 1074

Similar Papers

Loading similar papers…