RNAi, microRNAs, and human disease

@article{Hammond2006RNAiMA,
  title={RNAi, microRNAs, and human disease},
  author={S. Hammond},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2006},
  volume={58},
  pages={63-68}
}
  • S. Hammond
  • Published 2006
  • Biology, Medicine
  • Cancer Chemotherapy and Pharmacology
MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene expression. Over 300 miRNA genes have been identified in the human genome. We have undertaken the study of miRNA function in mammals. Using a custom microarray platform, we investigated miRNA expression patterns in mammalian development and in cancer. We found that many miRNAs are downregulated in cancer. On the other hand, several miRNA genes are overexpressed in tumor cell lines and primary tumors. Seven of… Expand
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