RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.

@article{OrrUrtreger2006RNASELMS,
  title={RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.},
  author={Avi Orr-Urtreger and Anat Bar-Shira and Dani Bercovich and Noa Matarasso and Uri Rozovsky and Serena Rosner and Sonya Soloviov and Gad Rennert and Luna Kadouri and Ayala Hubert and Hanna Rennert and Haim Matzkin},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2006},
  volume={15 3},
  pages={474-9}
}
Epidemiologic and genetic studies support the considerable effect of heritable factors on prostate tumorigenesis, although to date, no unequivocal susceptibility gene has been identified. The extensive study of RNASEL in prostate cancer patients worldwide has yielded conflicting results. We reevaluated the role of the RNASEL 471delAAAG Ashkenazi founder mutation in 1,642 Ashkenazi patients with prostate, bladder, breast/ovarian, and colon cancers; Ashkenazi controls; and in non-Ashkenazi… CONTINUE READING