RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae.

@article{Becker1995RNA1EA,
  title={RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae.},
  author={Jessica Becker and Frauke Melchior and Volker Gerke and F. Ralf Bischoff and Herwig Ponstingl and Alfred Wittinghofer},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 20},
  pages={11860-5}
}
Ran/TC4 is a ras-related GTP-binding protein predominantly located in the nucleus. Ran/TC4 is essential for nuclear transport and is involved in mitotic control. In Saccharomyces cerevisiae a gene highly homologous to Ran/TC4 has been identified and named GSP1. Like all ras-related GTP-binding proteins, Gsp1p undergoes cycles of GTP hydrolysis and GDP/GTP exchange. The switching between the two different nucleotide bound states regulates the function of these GTP-binding proteins. Here we… CONTINUE READING

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