RNA virus mutations and fitness for survival.

@article{Domingo1997RNAVM,
  title={RNA virus mutations and fitness for survival.},
  author={Esteban Domingo and John J. Holland},
  journal={Annual review of microbiology},
  year={1997},
  volume={51},
  pages={151-78}
}
RNA viruses exploit all known mechanisms of genetic variation to ensure their survival. Distinctive features of RNA virus replication include high mutation rates, high yields, and short replication times. As a consequence, RNA viruses replicate as complex and dynamic mutant swarms, called viral quasispecies. Mutation rates at defined genomic sites are affected by the nucleotide sequence context on the template molecule as well as by environmental factors. In vitro hypermutation reactions offer… CONTINUE READING
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