RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.

@article{Jennings2008RNAUA,
  title={RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.},
  author={Thomas A. Jennings and Yingfeng Chen and Deniz Sikora and Melody K Harrison and Bartek Sikora and Luyun Huang and Eckhard Jankowsky and Margaret E Fairman and Craig E Cameron and Kevin D. Raney},
  journal={Biochemistry},
  year={2008},
  volume={47 4},
  pages={1126-35}
}
Hepatitis C virus (HCV) infects over 170 million persons worldwide. It is the leading cause of liver disease in the U.S. and is responsible for most liver transplants. Current treatments for this infectious disease are inadequate; therefore, new therapies must be developed. Several labs have obtained evidence for a protein complex that involves many of the nonstructural (NS) proteins encoded by the virus. NS3, NS4A, NS4B, NS5A, and NS5B appear to interact structurally and functionally. In this… CONTINUE READING