RNA under attack: cellular handling of RNA damage.

  title={RNA under attack: cellular handling of RNA damage.},
  author={Elisabeth J Wurtmann and Sandra L Wolin},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={44 1},
Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to… CONTINUE READING
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