RNA transcription and translation in the hearts of normal and cardiomyopathic Syrian hamsters.

@article{McCully1991RNATA,
  title={RNA transcription and translation in the hearts of normal and cardiomyopathic Syrian hamsters.},
  author={J. D. McCully and John D. Mably and Michael Sole and Choong Chin Liew},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1991},
  volume={69 1},
  pages={88-92}
}
The cardiomyopathic Syrian hamster has an autosomal recessive defect that results in the development of an early onset cardiac myopathy leading to cardiac dysfunction and, eventually, complete heart failure. To assess the regulatory mechanisms modulating gene expression in the normal and myopathic myocardium, we investigated both RNA transcription and translation. Our results indicated that the incorporation of [3H]UMP into myocardial cell nuclear RNA decreased 10-fold from 7 to 210 days of age… CONTINUE READING
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