RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme

@article{Pyle1992RNASB,
  title={RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme},
  author={Anna M Pyle and Felicia L. Murphy and Thomas R Cech},
  journal={Nature},
  year={1992},
  volume={358},
  pages={123-128}
}
In catalysis by group I introns, the helix (P1) containing the RNA cleavage site must be positioned next to the guanosine binding site. We have identified a conserved adenine in the catalytic core that contributes to the stability of this arrangement and propose that it accepts a hydrogen bond from a specific 2′-OH in P1. Such base-backbone tertiary interactions may be generally important to the organization of RNA tertiary structure. 

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