RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

@inproceedings{Chapman2014RNAST,
  title={RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA},
  author={Erich G. Chapman and Stephanie L Moon and Jeffrey Wilusz and Jeffrey S Kieft},
  booktitle={eLife},
  year={2014}
}
Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell's RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis. Host cell exonuclease Xrn1 likely loads on the 5' end of viral genomic RNA and degrades processively through ∼10 kB of RNA, halting near the 3' end of the viral RNA. The surviving RNA is the sfRNA. We interrogated the architecture of the complete Dengue 2 sfRNA… CONTINUE READING
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